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<p class="cmp-title__text">Her2 lung cancer. A study now identifies selective HER2 .</p>
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<p>Her2 lung cancer Several therapies targeting HER2 are … May 29, 2024 · 8534Background: Mutations in the human epidermal growth factor receptor 2 (ERBB2; HER2) are oncogenic in lung adenocarcinoma (LUAD). Nov 1, 2017 · Background: Human epidermal growth factor receptor 2 (HER2) mutations have been reported in lung adenocarcinomas. 1 The development of HER2 inhibition for the treatment of lung cancer was Abstract Background. There is, to date, no standard of care for these patients. In particular, the HER2 exon 20 mutation is now a well clinically validated Oncogenic driver mutations have emerged as major treatment targets for molecular therapies in a variety of cancers. News release. 3 Apr 22, 2013 · HER2 mutations consist of in-frame insertions in exon 20, leading to constitutive activation of the receptor and downstream AKT and MEK pathways. Human epidermal growth factor receptor 2 (HER2) is a transmembrane glycoprotein receptor with intracellular tyrosine kinase activity. It is a HER2-targeted antibody-drug that is a combination of 2 cancer medications. Previously, treatment outcomes in HER2-mutant metastatic NSCLC were dismal, showing limited clinical benefit with platinum-based chemotherapy with or without imm Jan 19, 2022 · HER2 amplification is recognized as a frequent molecular abnormality and therapeutic target in breast and gastric cancer. 4 Inducible expression of a HER2 mutant (HER2YVMA) in lung epithelium of mice results in Aug 6, 2023 · HER2 mutations, which account for 2–4% of non-small cell lung cancer (NSCLC), are distinct molecular alterations identified via next generation sequencing (NGS). December 6, 2024. In 2018, there were 2. 6 Patients with HER2-mutant NSCLC are predominantly women, of younger Apr 5, 2024 · HER2-directed therapies have been used to treat breast, gastric, lung and colorectal cancers for a number of years. Among these patients, an ORR of 44% and a median PFS of 5 Apr 2, 2025 · HER2 amplification, characterized by an increased copy number of the HER2 gene, detected through fluorescent in situ hybridization (FISH) or NGS, occurs in approximately 2%–5% of lung adenocarcinoma cases. 80), especially in small cell lung cancer, adenocarcinoma and early NSCLC patients (18,19). Boehringer Ingelheim. Hum … Sep 9, 2024 · About non-small cell lung cancer (NSCLC) Lung cancer claims more lives than any other cancer type and the incidence is set to increase to over 3 million cases worldwide by 2040. Ado Trastuzumab–emtansine (T-DM1) is an ADC that links trastuzumab with a cytotoxic microtubule inhibitor, DM-1. Sep 3, 2015 · HER2 mutations have been identified as oncogenic drivers in lung cancers and are found in 1–2% of lung adenocarcinomas. The results of the HER2-mutant cohort (cohort 2 Sep 30, 2024 · Panelists discuss how HER2-directed therapies in non–small cell lung cancer (NSCLC) are evolving, with experts examining the distinction between HER2 mutation and expression, evaluating the 6 days ago · Lung cancer is the leading cause of cancer-related deaths in the U. However, not all oncogenic drivers, such as human epidermal growth factor receptor 2 (HER2), have approved targeted agents. reported inferior outcomes in patients with HER2-mutant NSCLC who received pemetrexed-based chemotherapy compared with those with ALK/ROS1 rearrangements, thus highlighting the need Abstract. NSCLC, non-small cell lung cancer; HER2, human epidermal growth factor receptor 2; DAR, drug-to-antibody ratio; ORR, objective response rate; PFS, progression-free survival; CI, confidence intervals; OS, overall survival; TRAE, treatment-related adverse event; IHC, immunohistochemistry 5 days ago · About Non-Small Cell Lung Cancer (NSCLC) Lung cancer is the leading cause of cancer-related deaths in the U. S. 22–1. Results from a trial showed that the drug might work on HER2-positive lung cancer. Feb 25, 2025 · We searched PubMed for clinical trials published in English between Jan 1, 2014, and Sep 30, 2024, using the terms “HER2-targeted” OR “HER2-mutant” OR “ERBB2-targeted” OR “ERBB2-mutant” AND “non-small cell lung cancer” OR “NSCLC”, as well as abstract records of the American Society of Clinical Oncology, European Society Dec 20, 2024 · Zongertinib (BI 1810631) continued to be efficacious and tolerable in patients with pretreated advanced non–small cell lung cancer (NSCLC) with HER2 mutations, according to updated findings from HER2 Patients: Gabrielle Goodman, Bill Brand. 3,6,7 Although HER2 is expressed in solid tumour types including biliary tract, bladder, cervical, endometrial, ovarian and pancreatic cancers, testing is not routinely performed in these additional tumour types and as a result . Laboratory methods for assessment of HER2 posi … May 4, 2021 · Oncogenic mutations and amplifications in the erythroblastic oncogene B (ERBB2), or human epidermal growth factor receptor 2 (HER2), have emerged as distinct oncogenic drivers and drug targets in non-small cell lung cancer (NSCLC). In this podcast we discuss the rare but significant presence of HER2 in lung cancer. 1,2. Most people are familiar with HER2 presence in breast cancer. Currently, targeted therapies are the standard treatment for most oncogene-driven patients [1]. Apr 22, 2025 · Background The objective of this study was to investigate the clinical and genetic characteristics and clinical relevance of HER2 exon 20 oncogenic variants in non-small cell lung cancer (NSCLC) patients. 29, 30, 31 Conversely, Wang et al. We’re honored to have one of the original investigators in the discovery of the EGFR mutation. Dec 1, 2023 · HER2 mutations, which account for 2–4% of non-small cell lung cancer (NSCLC), are distinct molecular alterations identified via next generation sequencing (NGS). An FDA-approved drug, trastuzumab deruxtecan, is now available as second line treatment (rx) of patients (pts) with HER2 Apr 28, 2025 · The Beamion LUNG-1 trial is investigating zongertinib as a monotherapy in previously treated patients with advanced or metastatic non-small cell lung cancer harboring HER2 mutations. 13-15 Only a small subset of patients harbor both HER2 mutation and co-occurring HER2 amplification, defining distinct clinical groups. About 2% of lung cancer patients have HER2 mutations. 11 However, studies addressing HER2/neu expression in patients with lung cancer have only DESTINY-Lung01 is a multicentre, open-label, phase 2 study evaluating the antitumour activity and safety of trastuzumab deruxtecan, a HER2-directed antibody-drug conjugate, in patients with HER2-overexpressing or HER2 (ERBB2)-mutant unresectable or metastatic non-small-cell lung cancer (NSCLC). The only currently approved treatment for this patient population is the antibody-drug conjugate trastuzumab deruxtecan (T-DXd), which is delivered intravenously Aug 27, 2022 · Human epidermal growth factor receptor 2 (HER2), a member of the ERBB family of tyrosine kinase receptors, has emerged as a therapeutic target of interest for non-small cell lung cancer (NSCLC) in recent years. T-DM1 was evaluated as part of a phase II basket trial in 18 HER2 mutant lung cancer patients, 11 with a HER2 exon 20 mutation, and 2 with a concurrent HER2 amplification. 6 80% of people diagnosed with NSCLC have already progressed to advanced stages, which makes Clinical trials evaluating antibody–drug conjugates in patients with NSCLC harboring HER2 aberrations. Mar 29, 2022 · Multiple oncogenic molecular alterations have been discovered that serve as potential drug targets in non-small cell lung cancer (NSCLC). HER2 mutations, which account for 2-4% of non-small cell lung cancer (NSCLC), are distinct molecular alterations identified via next generation sequencing (NGS). Dr. 1 Every year, about 40,000 people worldwide are diagnosed with non-small cell lung cancer (NSCLC) with a HER2 mutation. That’s slightly different from breast cancer, in which tumors can have high levels of the HER2 protein from gene overexpression, he said. 5 Alterations of HER2 in NSCLC include mutations in 1% to 7% of cases, overexpression in 8% to 23%, and amplification in 2% to 5%. One of these targeted treatments is trastuzumab emtansine. NSCLC is the most common type of lung cancer. 6 Patients with HER2-mutant NSCLC are predominantly women, of younger Lung cancer is currently the leading cause of cancer mortality worldwide for both men and women, and the rate continues to increase. Aug 31, 2021 · Lung cancer is the leading cause of cancer-related mortality worldwide. Following his HER2 Nov 22, 2016 · Background: ERBB2 (HER2) is a driver gene identified in non-small cell lung cancer (NSCLC). 1. 6 80% of people diagnosed with NSCLC have already progressed to advanced stages, which makes it more Jul 24, 2023 · Treatment of patients with HER2-mutant non-small-cell lung cancer with the pan-HER inhibitor pyrotinib in a phase 2 trial or compassionate use showed a favorable objective response rate, whereas A meta-analysis of 6,135 lung cancer patients shows that HER2 overexpression determined by IHC analysis is a marker of poor prognosis in NSCLC (HR 1. Mar 1, 2023 · Non-small cell lung cancer (NSCLC) is a heterogeneous disease characterized by a broad spectrum of oncogenic driver alterations. 1, 2 Targeted therapies directed against specific molecular aberrations, such as epidermal growth factor receptor (EGFR) and B-RAF proto Apr 28, 2025 · Innovative oral targeted therapies are warranted for patients with human epidermal growth factor receptor 2 (HER2)–mutant non–small-cell lung cancer (NSCLC). For example, HER2 plays a role in non–small-cell lung cancer (NSCLC). 8% of all cancer-related deaths. Methods This prospective study analyzed 51 NSCLC patients with HER2 mutations, identified via next-generation sequencing (NGS) of tissue, blood, cerebrospinal fluid, or pleural effusion Oct 23, 2023 · Dave Fredrickson, Executive Vice President, Oncology Business Unit, AstraZeneca, said: “Understanding the molecular drivers behind a lung cancer diagnosis is critical, and while there are now targeted options for many patients, those with HER2-mutant non-small cell lung cancer have had few treatment options, none of which have been approved Apr 28, 2025 · Boehringer and Bayer's oral meds deliver in early HER-2 mutant lung cancer studies. 8 million deaths in 2020 . Non-small-cell lung cancer (NSCLC), the main histologic subtype accounting for 85% of lung cancer cases, is a heterogeneous disease driven by a wide spectrum of molecular alterations. ). Every year, about 40,000 people worldwide are diagnosed with non-small cell lung cancer (NSCLC) with a HER2 mutation. We describe the prevalence, clinical features and outcomes associated with HER2 mutations in 1007 patients in the Lung Cancer Mutation Consortium (LCMC). We thus aim to study the therapeutic outcomes of patients harboring HER2 mutations and establish the efficacy of various drug regimens. Oct 1, 2024 · ERBB2 (HER2) represents a newly recognized actionable oncogenic driver in non-small cell lung cancer (NSCLC), with approved targeted therapy available. Overexpression of HER2/neu has been found in 10%–30% of different types of cancers, like breast cancers and gastric/gastroesophageal cancers, with prognostic and predictive value. 8 Evidence suggests that lung cancer is more common in women and Asians. In non-small-cell lung cancer (NSCLC), the identification of oncogenic driver mutations led to the definition of different clinical entities with different therapeutic opportunities, as demonstrated in patients harboring EGF receptor (EGFR) mutations or anaplastic lymphoma kinase translocations. Introduction. The efficacy and safety of trastuzumab Mar 15, 2025 · ERBB2 (HER2) alterations, including mutations, amplifications, and overexpression are emerging therapeutic targets in non-small cell lung cancer (NSCLC). Jul 2, 2022 · Human epidermal growth factor receptor 2 (HER2), a member of the ERBB family of tyrosine kinase receptors, has emerged as a therapeutic target of interest for non-small cell lung cancer (NSCLC) in recent years. Each genomic alteration occurs in 2–4% of NSCLC by next generation sequencing and is associated with Sep 10, 2024 · Speakers discussed unmet needs in lung cancer, future treatment perspectives, emerging therapies, and the selective targeting of HER2 in non–small cell lung cancer (NSCLC). Neal explained. 5 Non-Small Cell Lung Cancer (NSCLC) is the most common type of lung cancer, accounting for more than 85% of cases. 1 In 2015, there were 733,000 new lung cancer cases and 610,000 lung Jul 26, 2022 · Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in approximately 2% of patients with non-small cell lung cancer and predominantly affect the tyrosine kinase domain May 4, 2021 · Oncogenic mutations and amplifications in the erythroblastic oncogene B (ERBB2), or human epidermal growth factor receptor 2 (HER2), have emerged as distinct oncogenic drivers and drug targets in non-small cell lung cancer (NSCLC). Keypoints: • The significance of HER2 alterations in NSCLC and how they differ from breast and gastric cancers. 6% of all cancer cases, and 1. 2 While targeted therapy is available for some cancers driven by HER2, people living with HER2 mutation-positive NSCLC have continued high unmet needs. 5 Non-Small Cell Lung Cancer (NSCLC) is the most common type of lung cancer, accounting for more than 85% of cases. Previously, treatment outcomes in HER2-mutant metastatic NSCLC were dismal, showing limited clinical benefit with platinum-based chemother … Feb 2, 2013 · Epidemiology of HER2 mutations in lung cancer. 3 HER2 mutations respond to the genetic driver definition and preclinical models have proved the concept of transforming property of such a genetic alteration. Activating HER2 alterations in NSCLC include gene mutations, gene amplifications, and pro … Targeting HER2 in lung cancer. HER2 positivity has been well-studied in breast cancer, but its importance is still being explored in non-small cell lung cancer (NSCLC). Understanding the landscape of ERBB2 Apr 6, 2024 · HER2-directed therapies have been used to treat breast, gastric, lung and colorectal cancers for a number of years. The most meaningful type of HER2 mutation for treating lung cancer is called an exon 20 insertion. Who is most likely to have a HER2 oncogene? HER2 mutations tend to be more common in adenocarcinoma non-small cell lung cancer patients with little to no smoking history. The prevalence, clinicopathology, genetic variability and treatment of HER2-positive NSCLC in Chinese population are unclear. A study now identifies selective HER2 Sep 13, 2022 · The HER2 mutations seen in lung cancer make the HER2 protein activated all the time, Dr. Oct 13, 2023 · The tyrosine kinase human epidermal growth factor receptor 2 (HER2), also known as ERBB2, has been identified as a driver of cell proliferation and potential therapeutic target in lung cancer. Each genomic alteration occurs in 2–4% of NSCLC by next generation sequencing and is associated with Nov 22, 2016 · Background: ERBB2 (HER2) is a driver gene identified in non-small cell lung cancer (NSCLC). Zongertinib is an oral The study has 2 parts. • The complexities of biomarker testing, including NGS, IHC, and FISH amplification. The results, which were published in The New England Journal of Medicine, add to zogertinib’s known spread of Alterations in the HER2 gene are seen across different cancer types, including breast, gastric and lung cancer. Overexpression, amplification, and point mutations in HER2 have been described in patients with NSCLC; however, the potential roles of these alterations remain u Keywords: non-small cell lung cancer, oncogenic drivers, HER2 alterations, anti-HER2 targeted therapy. Aug 12, 2022 · This is the first antibody-drug conjugate (a type of precision medicine) for lung cancer, the first therapy targeting HER2 mutations in lung cancer, and the first HER2-targeted therapy for lung cancer to have received a Breakthrough Therapy designation from the FDA. 48; 95% CI: 1. The first part is open to adults with different types of advanced cancer with HER2 alterations that include mutations, amplifications, over-expression and fusions for whom previous treatment was not successful. 4 Activating HER2 mutations are found in 2% to 4% of advanced NSCLC. 1 In 2015, there were 733,000 new lung cancer cases and 610,000 lung Alterations in the HER2 gene are seen across different cancer types, including breast, gastric and lung cancer. Apr 30, 2025 · Nearly three quarters of non-small-cell lung cancer (NSCLC) patients with HER2 mutations experienced tumor regression when treated with zongertinib, a novel targeted therapy, according to results from the main cohort of an early study presented at the American Association for Cancer Research annual meeting (AACR 2025) and published in The New England Journal of Medicine. Its alterations, including mutation, amplification and overexpression, could result in oncogenic potential and have been detected in many cancers such as non-small-cell lung cancer (NSCLC). 80 million deaths from lung cancer, accounting for 18. Many prospective studies failed to identify an association between HER2 amplification or overexpression and response to conventional chemotherapy. Activating HER2 alterations in NSCLC include gene mutations, gene amplifications, and protein overexpression. 8 million new cases and an estimation of 1. The promise of targeted therapies . 4 Activating HER2 mutations are found in 2% to 4% of advanced NSCLC. Herein, the authors describe the prevalence, clinical features, and outcomes associated with HER2 mutations in 1007 patients in the Lung Cancer Mutation Consortium (LCMC). Apr 28, 2025 · CHICAGO – Zongertinib, a human epidermal growth factor receptor 2 (HER2)-targeted tyrosine kinase inhibitor, elicited durable responses in patients with advanced, previously treated non-small cell lung cancer (NSCLC) that harbored a HER2 mutation, according to results from the phase Ia/Ib Beamion LUNG-1 trial presented at the American Association for Cancer Research (AACR) Annual Meeting Jul 26, 2022 · Though HER2 (ERBB2) exon 20 insertion mutations occur in ~2% of non-small-cell lung cancers, molecular targeted therapies for such cancers have been lacking. The second part is open to people with HER2-mutant non-small cell lung cancer. Human epidermal growth factor receptor 2 (HER2) mutations have been reported in lung adenocarcinomas. Lung cancer is currently the second most commonly diagnosed and the deadliest cancer worldwide, with more than 2. ENHERTU is a prescription medicine used to treat adults who have non-small cell lung cancer (NSCLC) that has a certain mutation in the HER2 gene and cannot be removed by surgery or has spread to other parts of your body (metastatic), and who have received a prior treatment. 10 million new lung cancer cases, accounting for 11. Up to date, few studies regarding HER2 mutations in NSCLC have been published, primarily in Asian patient populations in which never smokers constitute a greater percentage of lung cancer patients (approximately 30%) compared to North American and European populations (10%). While the pathogenic and pharmacological features of common targets in NSCLC have been widely investigated, those of uncommon targets are still needed to be clari … Dec 13, 2024 · Updated data from Beamion LUNG-1 study on zongertinib shows encouraging efficacy in previously treated HER2 mutated lung cancer patients. The condition is often diagnosed at a late stage, and fewer than 3 in 10 patients are alive five years after diagnosis. Previously, treatment outcomes in HER2-mutant metastatic NSCLC were dismal, showing limited clinical benefit with platinum-based chemotherapy with or without imm This can also help keep the cancer from progressing. 3,6,7 Although HER2 is expressed in solid tumor types including biliary tract, bladder, cervical, endometrial, ovarian and pancreatic cancers, testing is not routinely performed in these additional tumor types and as a result Lung cancer is currently the leading cause of cancer mortality worldwide for both men and women, and the rate continues to increase. Trastuzumab deruxtecan was approved under accelerated approval. Apr 23, 2020 · HER2 is a critical gene that drives various solid tumors in addition to those of breast cancer. 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